Medical Research on Xanthones

1. Protective effects from irradiation-induced injury. Commercial, or medical radiation injury ..lowers damage, inflammations disturbances & pro-apoptotic alternations induced by IR.’
   https://pubmed.ncbi.nlm.nih.gov/34220386/
2. NEURO-PROTECTIVE effects on ALZHEIMER: can attenuate oxidative stress & inflammation..& also protect neurons against toxic injury, suggesting that it may exert a protective effect in AD https://pubmed.ncbi.nlm.nih.gov/34998794/
3. Demonstrates that mangostanin is effective in protecting the skin from the action of free radicals, thus PREVENTING SKIN AGING, confirming a potential toward its development in the nutraceutical and cosmeceutical fields https://pubmed.ncbi.nlm.nih.gov/35056141/
4. A summary available of the work that has been done to explore the anticancer & anti tumor activities of α-mangostin, lesser xanthones, and mangosteen extracts in vitro, in vivo, & in humans in various cancers https://pubmed.ncbi.nlm.nih.gov/34896543/
5. Protective effects against (a chemo therapy) doxorubicin-induced cardiotoxicity by antioxidant, anti inflammatory, and antiapoptotic effects that may ameliorate doxorubicin cardiotoxicity in human chemotherapy without reduction in its anticancer effect  https://pubmed.ncbi.nlm.nih.gov/34962009/

6. Mangosteen suppresses colon carcinogenesis (The process by which normal cells are transformed into cancer cells.) https://pubmed.ncbi.nlm.nih.gov/34802869/

7. Mangosteen peel extracts inhibit diabetic glomerulosclerosis condition (neuropathy) & may help increase helpful kidney cells https://www.ncbi.nlm.nih.gov/pubmed/30524699
8. Mangosteen pericarp has antibacterial effects, anti-inflammatory effect against methicillin-resistant Staphylococcus aureus (MRSA)-induced superficial skin infection   https://www.ncbi.nlm.nih.gov/pubmed/30611995
9. Alleviate stress induced liver fibrosis.  https://www.ncbi.nlm.nih.gov/pubmed/30502394
10. Helps collagen induced arthritis https://www.ncbi.nlm.nih.gov/pubmed/30484004
11. Mangosteen is stronger than milk thistle in protecting liver https://www.ncbi.nlm.nih.gov/pubmed/30306536
12. Suppress development of atherosclerosis https://www.ncbi.nlm.nih.gov/pubmed/30959963
13. Preclinical evidence proved helpful with scizophrenia. Controlled trial underway https://www.ncbi.nlm.nih.gov/pubmed/30905130
14. Check out the Table 1 & 2 for remarkable compilation of medical benefits  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368837/
15. Enhance memory and protect neurons effects of γ-mangostin. https://www.ncbi.nlm.nih.gov/pubmed/31019651
16. Mediated autoimmune diseases © 2019 Asia Pacific League of Associations for Rheumatology & protected from kidney damage https://www.ncbi.nlm.nih.gov/m/pubmed/31769201/
17. Reduce body weight, & the liver and kidney problems caused by high fat diet https://www.ncbi.nlm.nih.gov/pubmed/31791316
18. Significant improvement of severe acne, with no severe side effects like the drugs cause. https://www.ncbi.nlm.nih.gov/pubmed/30688020
19. Inhibits prostate cancer. Good for prevention and treatment https://www.ncbi.nlm.nih.gov/pubmed/31782573/
20. Anti tumor for glioblastoma! & squamous cell PLUS, for 1st time, anti nematode (parasites/worms) https://www.ncbi.nlm.nih.gov/pubmed/31542481
21. Protective role could be due to its efficacy to activate the Nrf-2 ! xanthones greatly improve tissue architecture from kidney damage https://www.ncbi.nlm.nih.gov/pubmed/31886417
22. Assists nerve development (protects against neurodegeneration ie: Alzheimer) AND is potent to stop breast cancer cells proliferation https://pubmed.ncbi.nlm.nih.gov/31711765/
23. Inhibits growth of Prostrate Cancer. prevention & treatment  https://pubmed.ncbi.nlm.nih.gov/31782573/
24. Prevent vascular complications caused by high glucose in patients with diabetes. https://pubmed.ncbi.nlm.nih.gov/31792920/
25.  Protective Anti-Inflammatory Activity Against Acute Lung Injury and Its Potential Cytotoxicity to Epithelial Lung and Breast Carcinomas 
    https://pubmed.ncbi.nlm.nih.gov/31218570/
26. Promising for the treatment of AD (Alzheimer Disease), PD (Parkinson Disease) and depression https://pubmed.ncbi.nlm.nih.gov/32867357/
27. Considered a potent anticancer agent for treating ORAL cancer & CERVICAL cancer https://pubmed.ncbi.nlm.nih.gov/32986355/
28. Activate Nrf2 pathways and protect intestinal barrier (leaky guy) https://pubmed.ncbi.nlm.nih.gov/33310139/
29. Reduced inflammation of ulcerative colitis https://pubmed.ncbi.nlm.nih.gov/32927006/

1. BREAST CANCER LINES: showed a significant reduction in cell adhesion that did not stimulate cell migration but, on the contrary, blunted cell motility. www.ncbi.nlm.nih.gov/pubmed/29333084
2. BREAST & LUNG CANCER: NEW Xanthones discovered. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma and breast carcinoma cell lines. www.ncbi.nlm.nih.gov/pubmed/29307236
3. OSTEOPOROSIS: fresh juice mixtures (mangosteen) can be used as a remedy for the prevention of postmenopausal osteoporosis  www.ncbi.nlm.nih.gov/pubmed/29387722
4. ARTHRITIS & JOINTS:  superior anti-inflammatory effects..regulation of immune functions was deeply involved in the therapeutic actions of mangosteen on Arthritis, and it was associated to the protection of joints www.ncbi.nlm.nih.gov/pubmed/29367090
5. LIVER DAMAGE from drugs remarkably enhanced  www.ncbi.nlm.nih.gov/pubmed/29790527
6. IMPROVES INSULIN SECRETION (diabetics) protects from apoptotic (cancer) www.ncbi.nlm.nih.gov/pubmed/29772703.
7. DIABETIC CHRONIC INFLAMMATIONS LESSENED in adipose (connective) tissue. Critical to avoid onset of of insulin resistance and type 2 diabetes  www.ncbi.nlm.nih.gov/pubmed/29446826
8. DIABETIC CONTROL of obesity, insulin resistance, and inflammation www.ncbi.nlm.nih.gov/pubmed/29747432
9. Thai Doctors unveil successful use mangosteen product with cancer patients.    https://www.youtube.com/watch?v=W03Hi-ErqhM\
10. Significantly reduced the production of inflammatory factors. a xanthone from mangosteen rind     https://www.ncbi.nlm.nih.gov/pubmed/30132203
11. PROVING αMangosteen inhibits the hallmark mechanisms of inflammation acts well as an anti-inflammatory agent. https://www.ncbi.nlm.nih.gov/pubmed/29953154
12. Primary LIVER CANCER results: mangosteen has been reported for its cell-death induction and its chemosensitizing and anti-metastatic properties in MANY cancer cell types, such as OVARIAN cancer, LUNG cancer, and hepatocellular  carcinoma. https://www.ncbi.nlm.nih.gov/pubmed/30195041
13. Apoptosis & significant anti-metastatic effect in anti-small-cell neuroendocrine carcinomas in a very aggressive form of prostrate cancer https://www.ncbi.nlm.nih.gov/pubmed/30340816
14. Mangosteen extract supplementation is effective in increasing muscle strength, muscle size and, total lean mass, as well as endurance performance. A controlled human trial in resistance trained adult males https://www.ncbi.nlm.nih.gov/pubmed/30348185
15. Alleviated acute lung injury inflammation https://www.ncbi.nlm.nih.gov/pubmed/30405740
16. Treatment for tuberculosis “Xanthones were previously proven to be effective against other bacterial infections such as Staphylococcus , therefore this prompted the team to investigate its potential in tackling multi-drug resistant TB bacteria.”  click here

2017 Research ::

1. Hepatocellular (liver), Breast, Colonrectal Cancer: natural cytotoxic agent against various cancers. click here
2. Anti Bacterial and anti fungal properties:  https://www.ncbi.nlm.nih.gov/pubmed/28208680
3. Anti Malaria.  https://www.ncbi.nlm.nih.gov/m/pubmed/28241761/?i=2&from=mangosteen%20xanthones
4. Druggability https://www.ncbi.nlm.nih.gov/m/pubmed/28284429/?i=1&from=mangosteen%20xanthones
5. Late stage APOPTOSIS “It is noteworthy that the new compound can promote cells apoptosis in late stage, having a remarkable inhibition effect..” https://www.ncbi.nlm.nih.gov/pubmed/28441346
6. Prevent Heart hypertension  garcinia mangostana…prevented the development of hypertension and cardiovascular remodeling induced by ..oxidative stress and inflammation”  https://www.ncbi.nlm.nih.gov/pubmed/28455132
7. Bile Duct CANCER cholangiocarcinoma: “α-mangostin from Garcinia mangostana pericarp could inhibit CCA cell proliferation by inducing apoptosis through the mitochondrial pathway; induce G1 cell-cycle arrest; and inhibit metastasis. Moreover, α-mangostin could inhibit CCA growth, i.e. reduce tumor mass (weight and size).”  https://www.ncbi.nlm.nih.gov/pubmed/28441703
8. PERIDONTAL disease…cavities, pockets, bleeding gums etc “significant improvement in the periodontal status with the application of mangostana gel in periodontal pockets” https://www.ncbi.nlm.nih.gov/pubmed/28321995
9. Efflux/detox the body from drug build up including chemo naturally with the mangosteen that is also be cancer preventative and anti tumor  https://www.ncbi.nlm.nih.gov/pubmed/28641010
10. COLITIS significantly prevented weight loss, reduced disease activity index scores, and preserved colon length. Findings suggest that MGE alleviates ulcerative colitis https://www.ncbi.nlm.nih.gov/pubmed/28654307
11. Anti-inflammatory results from naturally occurring mangosteen are better than its synthetic counterparts  https://www.ncbi.nlm.nih.gov/pubmed/28715912
12. Lowers Pancreatic CHOLESTEROL Hypercholesterolemia is a major risk factors for the development and progression of atherosclerosis. mangosteen can  prevent and treat cardiovascular diseases associated with hypercholesterolemia  https://www.ncbi.nlm.nih.gov/pubmed/28741279
13. Pancreatic Cancer mangosteen “can induce apoptosis and autophagy in pancreatic cancer cells” https://www.ncbi.nlm.nih.gov/pubmed/28822990
14. Ovarian Cancer Excellent effects in anticancer activities by inducing apoptosis and suppressing migration and invasion  https://www.ncbi.nlm.nih.gov/pubmed/28878295
15. Strong ANTIBACTERIAL properties in newly discovered xanthone click here.
16. Killing and eradicating DRUG RESISTANT staphylococci INFECTIONS click here
17. DIABETIC vascular complications protected click here
18. DEPRESSION behaviors are reversed by acute garcinia mangosteen treatment (mangosteen equals drug performance) click here
19. Delays progression of & has a potential therapeutic effect on OSTEO ARTHRITIS click here
20. A promising strategy against MELANOMA click here. And inhibits SKIN CANCER click here
21. ANTIVIRAL α-mangostin  INHIBITS severe DENV (mosquito borne virus) better than antiviral agent (ribavirin) and anti inflammatory drug (dexamethasone). click here
22. CERVICAL CANCER (2) dietary antioxidant α-mangostin could inhibit the tumor growth of cervical cancer cells. click here
23. KIDNEY CANCER α-mangostin suppresses cell migration and invasion… a promising anti-metastatic click here
24. ANTI INFLAMMATORY β-mangostin demonstrated better anti-inflammatory activity than synthetic drugs ! click here
25. FATTY LIVER and INSULIN RESISTANCE alpha mangostin ameliorates (makes it better) click here
26. HEART significantly increased myocardial relaxation click here
27. alpha-mangostin novel neuroprotective agent through intervention of multiple pathological processes of ALZHEIMERS DISEASE (AD) click here
28. PARKINSONS DISEASE α-mangostin has neuroprotective effects against related neuronal injury. click here
29. educed brain levels of Neuroinflammation in AD (Alzheimer Disease), PD (Parkinson’s Disease) MULTIPLE SCLEROSIS   evaluating alpha mangosteen as an adjuvant treatment in  neurodegenerative diseases. click here

2016 Research::

1. 1. Cervical Cancer:”Mangostin showed the strongest suppression of human cervical cancer”http://www.ncbi.nlm.nih.gov/m/pubmed/26781450/
   2. Breast Cancer: (#3 study) “α-mangostin may be used as food supplement ..therapeutic compound for breast cancer.” http://www.ncbi.nlm.nih.gov/m/pubmed/26892433/
   3. Tongue Cancer: “α-mangostin induces the apoptosis of …tongue carcinoma cell”http://www.ncbi.nlm.nih.gov/m/pubmed/26951885/
   4. Lung Cancer: “a natural xanthone, was isolated from Garcinia mangostana… Apoptosis (kills cancer cells) in Lung Cancer Cells and Decreases Xenograft Tumor Growth”http://www.ncbi.nlm.nih.gov/m/pubmed/26310849/
   5. Effective against Macular Degeneration.  “alpha-mangostin could suspend the onset and development of Age-related Macular Degeneration.” http://www.ncbi.nlm.nih.gov/pubmed/26888416
   6. Effective against Alzheimers Disease, and for therapy of the Disease. “natural xanthones have multifunctional activities against Alzheimer’s disease (AD) and..for the therapy of AD.”  http://www.ncbi.nlm.nih.gov/pubmed/27038926
   7. Effective to promote growth of Stem Cells (help repair brain injury or degenerative central nervous system diseases…develop garcinone D as a lead compound to promote the proliferation of endogenous neural stem cells (NSCs).” http://www.ncbi.nlm.nih.gov/pubmed/27177723
   8. Blood sugar control   https://www.ncbi.nlm.nih.gov/m/pubmed/27738860/?i=1&from=mangosteen+xanthones+2016
   9. Reduce inflammation    https://www.ncbi.nlm.nih.gov/m/pubmed/26895796/?i=6&from=mangosteen+xanthones+2016
   10. Reduce hypoglycemia/Possibly increase insulin https://www.ncbi.nlm.nih.gov/m/pubmed/27208974/?i=3&from=mangosteen+xanthones+2016

2013-2015 Research::

1. 1. 1. Mangosteen antibiotics against Super Bugs http://newshub.nus.edu.sg/headlines/1309/mangosteen_23Sep13.php
      2. Auto immune, arthritis help http://www.ncbi.nlm.nih.gov/pubmed/24738849
      3. Breast and prostate Cancer 2013 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693070/
      4. Colon Cancer http://www.ncbi.nlm.nih.gov/pubmed/23239542
      5. Bladder Cancer http://www.ncbi.nlm.nih.gov/pubmed/23682785
      6. Leukemia http://www.ncbi.nlm.nih.gov/pubmed/23734655
      7. Tongue Cancer http://www.ncbi.nlm.nih.gov/pubmed/24660467
      8. Stomach Cancer http://www.ncbi.nlm.nih.gov/pubmed/24976157
      9. Inhibits Human Cancer. Anti proliferation http://www.ncbi.nlm.nih.gov/pubmed/23811100
      10. Liver Cancer (hepatocellular) Antitumour http://www.ncbi.nlm.nih.gov/pubmed/23927480
      11. Skin Cancer http://www.ncbi.nlm.nih.gov/pubmed/22993323
      12. Alzheimers and Cognition http://www.ncbi.nlm.nih.gov/pubmed/25525451
      13. Anti-Obesity http://www.ncbi.nlm.nih.gov/pubmed/25520256
      14. Multiple Pharmalogical Properties http://www.ncbi.nlm.nih.gov/pubmed/25518194
      15. Dental Caries Prevention http://www.ncbi.nlm.nih.gov/pubmed/25498719
      16. Preventing/treating Acne without toxicity http://www.ncbi.nlm.nih.gov/pubmed/24327275
      17. Treatment of inflammatory conditions (Cox-2 inhibition means lowers pain and inflammation)http://www.ncbi.nlm.nih.gov/pubmed/24607509
      18.  Eradicate liver cancer cells http://www.ncbi.nlm.nih.gov/m/pubmed/25955534/?i=15&from=mangosteen
      19. Improvement of skin conditions http://www.ncbi.nlm.nih.gov/m/pubmed/26236097/?i=8&from=mangosteen
      20. Lupus http://www.ncbi.nlm.nih.gov/m/pubmed/26330173/?i=5&from=mangosteen
      21. Regulating Metabolism. http://www.ncbi.nlm.nih.gov/m/pubmed/26452017/?i=2&from=mangosteen
      22. 46% reduction of C Reactive Protein markers (inflammation levels in blood) in the test group drinking a mangosteen based beverage. No side effects! http://www.ncbi.nlm.nih.gov/pubmed/26286710

Daily I use a Patented wholefood puree of mangosteen, that tastes great!!! 

Excellent article on mangosteen CLICK HERE

—My personal choice of  Mangosteen juice is the original whole fruit formula by Isagenix, Xango.

Buy  Canada CLICK HERE     USA   CLICK HERE  Questions? other market? Contact me CLICK HERE

The rind of the mangosteen fruit is considered by those familiar with it to be perhaps the most formidable, natural, herbal healing substance* on the whole of the Earth. The totally unique thing about the Mangosteen fruit is that it is the only fruit in the world that contains such a massive arsenal of  natural phytochemicals, all in one fruit.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.