Medical Research on Xanthones

Exceptional research by the science community— Link at bottom of this article for NSF mangosteen product I use.
  1. Protective effects from irradiation-induced injury. Commercial, or medical radiation injury ..lowers damage, inflammations disturbances & pro-apoptotic alternations induced by IR.’
  2. NEURO-PROTECTIVE effects on ALZHEIMER: can attenuate oxidative stress & inflammation..& also protect neurons against toxic injury, suggesting that it may exert a protective effect in AD
  3. Demonstrates that mangostanin is effective in protecting the skin from the action of free radicals, thus PREVENTING SKIN AGING, confirming a potential toward its development in the nutraceutical and cosmeceutical fields
  4. A summary available of the work that has been done to explore the anticancer & anti tumor activities of α-mangostin, lesser xanthones, and mangosteen extracts in vitro, in vivo, & in humans in various cancers
  5. Protective effects against (a chemo therapy) doxorubicin-induced cardiotoxicity by antioxidant, anti inflammatory, and antiapoptotic effects that may ameliorate doxorubicin cardiotoxicity in human chemotherapy without reduction in its anticancer effect
  6. Mangosteen suppresses colon carcinogenesis (The process by which normal cells are transformed into cancer cells.)

  7. Mangosteen peel extracts inhibit diabetic glomerulosclerosis condition (neuropathy) & may help increase helpful kidney cells
  8. Mangosteen pericarp has antibacterial effects, anti-inflammatory effect against methicillin-resistant Staphylococcus aureus (MRSA)-induced superficial skin infection
  9. Alleviate stress induced liver fibrosis.
  10. Helps collagen induced arthritis
  11. Mangosteen is stronger than milk thistle in protecting liver
  12. Suppress development of atherosclerosis
  13. Preclinical evidence proved helpful with scizophrenia. Controlled trial underway
  14. Check out the Table 1 & 2 for remarkable compilation of medical benefits
  15. Enhance memory and protect neurons effects of γ-mangostin.
  16. Mediated autoimmune diseases © 2019 Asia Pacific League of Associations for Rheumatology & protected from kidney damage
  17. Reduce body weight, & the liver and kidney problems caused by high fat diet
  18. Significant improvement of severe acne, with no severe side effects like the drugs cause
  19. Inhibits prostate cancer. Good for prevention and treatment
  20. Anti tumor for glioblastoma! & squamous cell PLUS, for 1st time, anti nematode (parasites/worms)
  21. Protective role could be due to its efficacy to activate the Nrf-2 ! xanthones greatly improve tissue architecture from kidney damage
  22. Assists nerve development (protects against neurodegeneration ie: Alzheimer) AND is potent to stop breast cancer cells proliferation
  23. Inhibits growth of Prostrate Cancer. prevention & treatment
  24. Prevent vascular complications caused by high glucose in patients with diabetes.
  25.  Protective Anti-Inflammatory Activity Against Acute Lung Injury and Its Potential Cytotoxicity to Epithelial Lung and Breast Carcinomas
  26. Promising for the treatment of AD (Alzheimer Disease), PD (Parkinson Disease) and depression
  27. Considered a potent anticancer agent for treating ORAL cancer & CERVICAL cancer
  28. Activate Nrf2 pathways and protect intestinal barrier (leaky guy)
  29. Reduced inflammation of ulcerative colitis
2018 Research:: 
  1. BREAST CANCER LINES: showed a significant reduction in cell adhesion that did not stimulate cell migration but, on the contrary, blunted cell motility.
  2. BREAST & LUNG CANCER: NEW Xanthones discovered. Compound 5 showed significant cytotoxic potential against epithelial lung carcinoma and breast carcinoma cell lines.
  3. OSTEOPOROSIS: fresh juice mixtures (mangosteen) can be used as a remedy for the prevention of postmenopausal osteoporosis
  4. ARTHRITIS & JOINTS superior anti-inflammatory effects..regulation of immune functions was deeply involved in the therapeutic actions of mangosteen on Arthritis, and it was associated to the protection of joints
  5. LIVER DAMAGE from drugs remarkably enhanced
  6. IMPROVES INSULIN SECRETION (diabetics) protects from apoptotic (cancer)
  7. DIABETIC CHRONIC INFLAMMATIONS LESSENED in adipose (connective) tissue. Critical to avoid onset of of insulin resistance and type 2 diabetes
  8. DIABETIC CONTROL of obesity, insulin resistance, and inflammation
  9. Thai Doctors unveil successful use mangosteen product with cancer patients.\
  10. Significantly reduced the production of inflammatory factors. a xanthone from mangosteen rind
  11. PROVING αMangosteen inhibits the hallmark mechanisms of inflammation acts well as an anti-inflammatory agent.
  12. Primary LIVER CANCER results: mangosteen has been reported for its cell-death induction and its chemosensitizing and anti-metastatic properties in MANY cancer cell types, such as OVARIAN cancer, LUNG cancer, and hepatocellular  carcinoma.
  13. Apoptosis & significant anti-metastatic effect in anti-small-cell neuroendocrine carcinomas in a very aggressive form of prostrate cancer
  14. Mangosteen extract supplementation is effective in increasing muscle strength, muscle size and, total lean mass, as well as endurance performance. A controlled human trial in resistance trained adult males
  15. Alleviated acute lung injury inflammation
  16. Treatment for tuberculosis Xanthones were previously proven to be effective against other bacterial infections such as Staphylococcus , therefore this prompted the team to investigate its potential in tackling multi-drug resistant TB bacteria.”  click here

2017 Research ::

  1. Hepatocellular (liver), Breast, Colonrectal Cancer: natural cytotoxic agent against various cancers. click here
  2. Anti Bacterial and anti fungal properties:
  3. Anti Malaria.
  4. Druggability
  5. Late stage APOPTOSIS “It is noteworthy that the new compound can promote cells apoptosis in late stage, having a remarkable inhibition effect..”
  6. Prevent Heart hypertension  garcinia mangostana…prevented the development of hypertension and cardiovascular remodeling induced by ..oxidative stress and inflammation”
  7. Bile Duct CANCER cholangiocarcinoma: “α-mangostin from Garcinia mangostana pericarp could inhibit CCA cell proliferation by inducing apoptosis through the mitochondrial pathway; induce G1 cell-cycle arrest; and inhibit metastasis. Moreover, α-mangostin could inhibit CCA growth, i.e. reduce tumor mass (weight and size).”
  8. PERIDONTAL disease…cavities, pockets, bleeding gums etc “significant improvement in the periodontal status with the application of mangostana gel in periodontal pockets”
  9. Efflux/detox the body from drug build up including chemo naturally with the mangosteen that is also be cancer preventative and anti tumor
  10. COLITIS significantly prevented weight loss, reduced disease activity index scores, and preserved colon length. Findings suggest that MGE alleviates ulcerative colitis
  11. Anti-inflammatory results from naturally occurring mangosteen are better than its synthetic counterparts
  12. Lowers Pancreatic CHOLESTEROL Hypercholesterolemia is a major risk factors for the development and progression of atherosclerosis. mangosteen can  prevent and treat cardiovascular diseases associated with hypercholesterolemia
  13. Pancreatic Cancer mangosteen “can induce apoptosis and autophagy in pancreatic cancer cells”
  14. Ovarian Cancer Excellent effects in anticancer activities by inducing apoptosis and suppressing migration and invasion
  15. Strong ANTIBACTERIAL properties in newly discovered xanthone click here.
  16. Killing and eradicating DRUG RESISTANT staphylococci INFECTIONS click here
  17. DIABETIC vascular complications protected click here
  18. DEPRESSION behaviors are reversed by acute garcinia mangosteen treatment (mangosteen equals drug performanceclick here
  19. Delays progression of & has a potential therapeutic effect on OSTEO ARTHRITIS click here
  20. A promising strategy against MELANOMA click here. And inhibits SKIN CANCER click here
  21. ANTIVIRAL α-mangostin  INHIBITS severe DENV (mosquito borne virus) better than antiviral agent (ribavirin) and anti inflammatory drug (dexamethasone). click here
  22. CERVICAL CANCER (2) dietary antioxidant α-mangostin could inhibit the tumor growth of cervical cancer cells. click here
  23. KIDNEY CANCER α-mangostin suppresses cell migration and invasion… a promising anti-metastatic click here
  24. ANTI INFLAMMATORY β-mangostin demonstrated better anti-inflammatory activity than synthetic drugs ! click here
  25. FATTY LIVER and INSULIN RESISTANCE alpha mangostin ameliorates (makes it better) click here
  26. HEART significantly increased myocardial relaxation click here
  27. alpha-mangostin novel neuroprotective agent through intervention of multiple pathological processes of ALZHEIMERS DISEASE (AD) click here
  28. PARKINSONS DISEASE α-mangostin has neuroprotective effects against related neuronal injury. click here
  29. educed brain levels of Neuroinflammation in AD (Alzheimer Disease), PD (Parkinson’s Disease) MULTIPLE SCLEROSIS   evaluating alpha mangosteen as an adjuvant treatment in  neurodegenerative diseases. click here

2016 Research::

    1. Cervical Cancer:”Mangostin showed the strongest suppression of human cervical cancer
    2. Breast Cancer: (#3 study) “α-mangostin may be used as food supplement ..therapeutic compound for breast cancer.”
    3. Tongue Cancer: “α-mangostin induces the apoptosis of …tongue carcinoma cell”
    4. Lung Cancer: a natural xanthone, was isolated from Garcinia mangostana… Apoptosis (kills cancer cells) in Lung Cancer Cells and Decreases Xenograft Tumor Growth”
    5. Effective against Macular Degeneration.  “alpha-mangostin could suspend the onset and development of Age-related Macular Degeneration.”
    6. Effective against Alzheimers Disease, and for therapy of the Disease. “natural xanthones have multifunctional activities against Alzheimer’s disease (AD) and..for the therapy of AD.”
    7. Effective to promote growth of Stem Cells (help repair brain injury or degenerative central nervous system diseases…develop garcinone D as a lead compound to promote the proliferation of endogenous neural stem cells (NSCs).”
    8. Blood sugar control
    9. Reduce inflammation
    10. Reduce hypoglycemia/Possibly increase insulin

2013-2015 Research::

      1. Mangosteen antibiotics against Super Bug
      2. Auto immune, arthritis help
      3. Breast and prostate Cancer 2013
      4. Colon Cancer
      5. Bladder Cancer
      6. Leukemia
      7. Tongue Cancer
      8. Stomach Cancer
      9. Inhibits Human Cancer. Anti proliferation
      10. Liver Cancer (hepatocellular) Antitumour
      11. Skin Cancer
      12. Alzheimers and Cognition
      13. Anti-Obesity
      14. Multiple Pharmalogical Properties
      15. Dental Caries Prevention
      16. Preventing/treating Acne without toxicity
      17. Treatment of inflammatory conditions (Cox-2 inhibition means lowers pain and inflammation)
      18.  Eradicate liver cancer cells
      19. Improvement of skin conditions
      20. Lupus
      21. Regulating Metabolism
      22. 46% reduction of C Reactive Protein markers (inflammation levels in blood) in the test group drinking a mangosteen based beverage. No side effects!

Daily I use a Patented wholefood puree of mangosteen, that tastes great!!! 

Excellent article on mangosteen CLICK HERE

—My personal choice of  Mangosteen juice is the original whole fruit formula by Isagenix, Xango.

Buy  Canada CLICK HERE     USA   CLICK HERE  Questions? other market? Contact me CLICK HERE

The rind of the mangosteen fruit is considered by those familiar with it to be perhaps the most formidable, natural, herbal healing substance* on the whole of the Earth. The totally unique thing about the Mangosteen fruit is that it is the only fruit in the world that contains such a massive arsenal of  natural phytochemicals, all in one fruit.

*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

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